BDBM407076 6-(3-cyanopyrrolo[1,2-b] pyridazin-7- yl)-N-((R)-2-fluoro-3- hydroxy-3- methylbutyl)-4- (((1R,3r,5S)-8- (methylsulfonyl)-8- azabicyclo[3.2.1]octan-3- yl)amino)nicotinamide::US10336762, Compound 15::US10336762, Compound 29

SMILES CC(C)(O)[C@H](F)CNC(=O)c1cnc(cc1NC1CC2CCC(C1)N2S(C)(=O)=O)-c1ccc2cc(cnn12)C#N

InChI Key InChIKey=XRRHSDJFZYHQNQ-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 407076   

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407076(US10336762, Compound 29 | 6-(3-cyanopyrrolo[1,2-b]...)
Affinity DataEC50:  302nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407076(US10336762, Compound 29 | 6-(3-cyanopyrrolo[1,2-b]...)
Affinity DataIC50: 4nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407076(US10336762, Compound 29 | 6-(3-cyanopyrrolo[1,2-b]...)
Affinity DataEC50:  100nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407076(US10336762, Compound 29 | 6-(3-cyanopyrrolo[1,2-b]...)
Affinity DataIC50: 1nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent