BDBM407028 Methyl N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]carbamate::US10336761, Example 312

SMILES COC(=O)Nc1cc(Nc2nc(nn3cccc23)-c2cccc(n2)C(F)(F)F)ccn1

InChI Key InChIKey=WHLFPDZLZRHZBN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 407028   

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM407028(Methyl N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]p...)
Affinity DataIC50: 0.870nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTGF-beta receptor type-2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM407028(Methyl N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]p...)
Affinity DataIC50: 1.50E+4nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent