BDBM406074 1-(2-phenyl-2,4,5,6- tetrahydrocyclopenta[c] pyrazol-3-yl)-3-(2-(2,2,2- trifluoroethyl)-1,2,3,4- tetrahydroisoquinolin-4- yl)urea::US10351575, Example 28::US10889589, EX. # 28

SMILES FC(F)(F)CN1CC(NC(=O)Nc2c3CCCc3nn2-c2ccccc2)c2ccccc2C1

InChI Key InChIKey=OLVXRIQHWITBPL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 406074   

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandPNGBDBM406074(1-(2-phenyl-2,4,5,6- tetrahydrocyclopenta[c] pyraz...)
Affinity DataIC50: 100nMAssay Description:TrkA binding activity was determined in a TrkA LanthaScreen Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandPNGBDBM406074(1-(2-phenyl-2,4,5,6- tetrahydrocyclopenta[c] pyraz...)
Affinity DataIC50: 100nMAssay Description:TrkA binding activity was determined in a TrkA LanthaScreen Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent