BDBM405829 US10351548, Compound DF8

SMILES Fc1ccc(Cn2cccc(C(=O)NCCCC(=O)Nc3ccc4NC(=O)\C(=C/c5cnc[nH]5)c4c3)c2=O)cc1F

InChI Key InChIKey=WSCBMCCISYODBR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 405829   

Target3-phosphoinositide-dependent protein kinase 1(Human)
International Society For Drug Development

US Patent
LigandPNGBDBM405829(US10351548, Compound DF8)
Affinity DataIC50: 245nMAssay Description:Factor IX is a key component of the plasma system that forms a fibrin clot at a site of vascular injury. The activity of Factor IXa is measured by mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2020
Entry Details
Go to US Patent

LigandPNGBDBM405829(US10351548, Compound DF8)
Affinity DataIC50: 245nMAssay Description:Inhibition of recombinant full length human His-tagged PDK1 expressed in Baculovirus expression system in presence of ATP measured by Bradford protei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM405829(US10351548, Compound DF8)
Affinity DataIC50: 611nMAssay Description:Inhibition of recombinant full length human His-tagged AURA expressed in Baculovirus expression system in presence of ATP measured by Bradford protei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed