BDBM404623 4-{1-[(2-chloro-6- cyclopropylphenyl) carbonyl]-1,4,5,7- tetrahydropyrano[3,4- c]pyrazol-3- yl}cyclohex-3-ene-1- carboxylic acid::US10344000, Example 1B

SMILES OC(=O)C1CCC(=CC1)c1nn(C(=O)c2c(Cl)cccc2C2CC2)c2COCCc12

InChI Key InChIKey=IASCSMPEGOLIMN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 404623   

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM404623(4-{1-[(2-chloro-6- cyclopropylphenyl) carbonyl]-1,...)
Affinity DataIC50: 73nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2020
Entry Details
Go to US Patent