BDBM404265 US10017502, Example 4a

SMILES CNC(=O)C[C@@H]1COc2cc(F)ccc2N1C(=O)c1ccc2OCC(=O)Nc2c1

InChI Key InChIKey=MBKYLPOPYYLTNW-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 404265   

TargetMineralocorticoid receptor [729-984](Human)
Astrazeneca

US Patent
LigandPNGBDBM404265(US10017502, Example 4a)
Affinity DataIC50: 130nMAssay Description:Test A1 and A2: In order to identify binding to the human MR LBD a scintillation proximity assay (SPA) was adapted to the 384-well format. The MR-LBD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
Go to US Patent

TargetMineralocorticoid receptor [729-984](Human)
Astrazeneca

US Patent
LigandPNGBDBM404265(US10017502, Example 4a)
Affinity DataIC50: 240nMAssay Description:Test A1 and A2: In order to identify binding to the human MR LBD a scintillation proximity assay (SPA) was adapted to the 384-well format. The MR-LBD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
Go to US Patent

TargetMineralocorticoid receptor(Human)
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM404265(US10017502, Example 4a)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at gal4-fused human mineralocorticoid receptor LBD expressed in UAS-MR-bla HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM404265(US10017502, Example 4a)
Affinity DataKi: <1.00E+4nMAssay Description:Displacement of [3H]-aldosterone to human mineralocorticoid receptor LBD by radiometric binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed