BDBM403834 (2S,5R)-5-(2-chlorophenyl)-1-(6-(2-chlorophenyl)nicotinoyl)pyrrolidine-2-carboxylic acid::US10017468, Compound 77::US10781171, Compound 77::US11072582, Compound 77

SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)c1ccc(nc1)-c1ccccc1Cl)c1ccccc1Cl

InChI Key InChIKey=JHZAQWMUTJYXKS-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 403834   

TargetFree fatty acid receptor 2(Human)
Epics Therapeutics

US Patent
LigandPNGBDBM403834((2S,5R)-5-(2-chlorophenyl)-1-(6-(2-chlorophenyl)ni...)
Affinity DataEC50: <200nMAssay Description:The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetFree fatty acid receptor 2(Human)
Epics Therapeutics

US Patent
LigandPNGBDBM403834((2S,5R)-5-(2-chlorophenyl)-1-(6-(2-chlorophenyl)ni...)
Affinity DataEC50: <200nMAssay Description:The following assay can be used for determination of GPR43 activation. When a GPCR is in its active state, either as a result of ligand binding or co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
Go to US Patent

TargetFree fatty acid receptor 2(Human)
Epics Therapeutics

US Patent
LigandPNGBDBM403834((2S,5R)-5-(2-chlorophenyl)-1-(6-(2-chlorophenyl)ni...)
Affinity DataEC50: <200nMAssay Description:The assay was used to determine the activity of the compounds of the invention.The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2021
Entry Details
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TargetFree fatty acid receptor 2(Human)
Epics Therapeutics

US Patent
LigandPNGBDBM403834((2S,5R)-5-(2-chlorophenyl)-1-(6-(2-chlorophenyl)ni...)
Affinity DataEC50: <200nMAssay Description:The assay was used to determine the activity of the compounds of the invention. The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2022
Entry Details
Go to US Patent