BDBM403460 US10335399, Example 2-5::US10806724, Example 2-5

SMILES CC1(C)CCc2c(O1)nc(cc2-c1ccc(F)cc1F)C(N)=O

InChI Key InChIKey=IDHJIKSQWCGDIP-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 403460   

TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM403460(US10335399, Example 2-5 | US10806724, Example 2-5)
Affinity DataIC50: 6nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM403460(US10335399, Example 2-5 | US10806724, Example 2-5)
Affinity DataIC50: 6nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM403460(US10335399, Example 2-5 | US10806724, Example 2-5)
Affinity DataIC50: 6nMAssay Description:Negative allosteric modulation activity at human recombinant mGlur2 expressed in CHO cells in presence of cAMP by chemiluminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM403460(US10335399, Example 2-5 | US10806724, Example 2-5)
Affinity DataKi:  59nMAssay Description:Binding affinity to human recombinant mGlur2 assessed as inhibition constant by cAMP Glosensor assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM403460(US10335399, Example 2-5 | US10806724, Example 2-5)
Affinity DataKi:  59nMAssay Description:Binding affinity to human recombinant mGlur2 assessed as inhibition constant by cAMP Glosensor assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed