BDBM402676 N-[3-(difluoromethyl)-1- methyl-1H-pyrazol-4-yl]- 2-{[(1R,2S)-2- hydroxycyclohexyl]amino}- pyrrolo[2,1- f][1,2,4]triazine-7- carboxamide trifluoroacetate::US10329295, Example 17

SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCC[C@@H]4O)nn23)c(n1)C(F)F

InChI Key InChIKey=ZTMFKTUXPAMBKI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 402676   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402676(US10329295, Example 17 | N-[3-(difluoromethyl)-1- ...)
Affinity DataIC50: 4nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
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Date in BDB:
5/31/2020
Entry Details
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