BDBM402486 2-[(3R)-3-aminopiperidin- 1-yl]-N-[1-methyl-3- (trifluoromethyl)-1H- pyrazol-4-yl]pyrrolo[2,1- f][1,2,4]triazine-7- carboxamide trifluoroacetate::US10329295, Example 7

SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2CCC[C@@H](N)C2)c(n1)C(F)(F)F

InChI Key InChIKey=BHAAMBUMNOPSIZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 402486   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402486(US10329295, Example 7 | 2-[(3R)-3-aminopiperidin- ...)
Affinity DataIC50: 0.900nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
Go to US Patent