BDBM399973 US10323042, Example 53A::US10323042, Example 53B::US10738063, Example 53B

SMILES Cc1cc(C#N)c(F)cc1-c1c(nn2C[C@H](F)COc12)C(=O)NC1CC1

InChI Key InChIKey=CICKNGAWODWCEX-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 399973   

LigandPNGBDBM399973(US10323042, Example 53A | US10323042, Example 53B ...)
Affinity DataIC50: 10.6nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM399973(US10323042, Example 53A | US10323042, Example 53B ...)
Affinity DataIC50: 5.35nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM399973(US10323042, Example 53A | US10323042, Example 53B ...)
Affinity DataIC50: 74.7nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM399973(US10323042, Example 53A | US10323042, Example 53B ...)
Affinity DataIC50: 312nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM399973(US10323042, Example 53A | US10323042, Example 53B ...)
Affinity DataIC50: 29.2nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM399973(US10323042, Example 53A | US10323042, Example 53B ...)
Affinity DataIC50: 6.45nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM399973(US10323042, Example 53A | US10323042, Example 53B ...)
Affinity DataIC50: 75.9nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM399973(US10323042, Example 53A | US10323042, Example 53B ...)
Affinity DataIC50: 337nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM399973(US10323042, Example 53A | US10323042, Example 53B ...)
Affinity DataIC50: 10.6nMAssay Description:Human PDE4B1 coding sequence (amino acids 122 to 736 from the sequence with accession number Q07343) with the mutations resulting in the amino acid s...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM399973(US10323042, Example 53A | US10323042, Example 53B ...)
Affinity DataIC50: 5.35nMAssay Description:Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM399973(US10323042, Example 53A | US10323042, Example 53B ...)
Affinity DataIC50: 74.7nMAssay Description:Human PDE4C1 coding sequence (amino acids 2 to 712 from the sequence with accession number NP_000914.2) was cloned into the baculovirus expression ve...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM399973(US10323042, Example 53A | US10323042, Example 53B ...)
Affinity DataIC50: 312nMAssay Description:A portion of the human PDE4D3 coding sequence (amino acids 50 to 672 from the sequence with accession number Q08499-2) was cloned into the baculoviru...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM399973(US10323042, Example 53A | US10323042, Example 53B ...)
Affinity DataIC50: 29.2nMAssay Description:Human PDE4B1 coding sequence (amino acids 122 to 736 from the sequence with accession number Q07343) with the mutations resulting in the amino acid s...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM399973(US10323042, Example 53A | US10323042, Example 53B ...)
Affinity DataIC50: 6.45nMAssay Description:Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM399973(US10323042, Example 53A | US10323042, Example 53B ...)
Affinity DataIC50: 75.9nMAssay Description:Human PDE4C1 coding sequence (amino acids 2 to 712 from the sequence with accession number NP_000914.2) was cloned into the baculovirus expression ve...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM399973(US10323042, Example 53A | US10323042, Example 53B ...)
Affinity DataIC50: 337nMAssay Description:A portion of the human PDE4D3 coding sequence (amino acids 50 to 672 from the sequence with accession number Q08499-2) was cloned into the baculoviru...More data for this Ligand-Target Pair
In DepthDetails
US Patent