BDBM396785 US9981944, Example 130::ethyl 5-(5'-fluoro-6'-methyl-[2,2'-bipyridin]-3- yl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

SMILES CCOC(=O)c1cnn2ccc(nc12)-c1cccnc1-c1ccc(F)c(C)n1

InChI Key InChIKey=WFQBACJZFNFDAD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 396785   

TargetTGF-beta receptor type-1 [T204D](Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM396785(US9981944, Example 130 | ethyl 5-(5'-fluoro-6'-met...)
Affinity DataIC50: 14nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
Go to US Patent

TargetTGF-beta receptor type-2(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM396785(US9981944, Example 130 | ethyl 5-(5'-fluoro-6'-met...)
Affinity DataIC50: 1.50E+4nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
Go to US Patent