BDBM396764 6-(6'-(difluoromethyl)-[2,2'-bipyridin]-3- yl)quinazolin-4-amine::US9981944, Example 109

SMILES Nc1ncnc2ccc(cc12)-c1cccnc1-c1cccc(n1)C(F)F

InChI Key InChIKey=VOZYQUZWOHRZRX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 396764   

TargetTGF-beta receptor type-1 [T204D](Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM396764(US9981944, Example 109 | 6-(6'-(difluoromethyl)-[2...)
Affinity DataIC50: 2nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
Go to US Patent

TargetTGF-beta receptor type-2(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM396764(US9981944, Example 109 | 6-(6'-(difluoromethyl)-[2...)
Affinity DataIC50: 1.50E+4nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
Go to US Patent