BDBM396735 6-(5-fluoro-6'-methyl-[2,2'-bipyridin]-3- yl)imidazo[1,2-a]pyridine-3-carbonitrile::US9981944, Example 81

SMILES Cc1cccc(n1)-c1ncc(F)cc1-c1ccc2ncc(C#N)n2c1

InChI Key InChIKey=CLWHNLGCPYGPJJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 396735   

TargetTGF-beta receptor type-1 [T204D](Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM396735(US9981944, Example 81 | 6-(5-fluoro-6'-methyl-[2,2...)
Affinity DataIC50: 16nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
Go to US Patent

TargetTGF-beta receptor type-2(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM396735(US9981944, Example 81 | 6-(5-fluoro-6'-methyl-[2,2...)
Affinity DataIC50: 1.50E+4nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
Go to US Patent