BDBM395689 (2R,5R)-5-(3-cyclopropyl-1,2,4- oxadiazol-5-yl)-2-methyl-1-{[2- (2H-1,2,3-triazol-2- yl)phenyl]carbonyl}piperidine::US10308645, Example 28

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1nc(no1)C1CC1

InChI Key InChIKey=XBTKDHZZNOUBMP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 395689   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM395689(US10308645, Example 28 | (2R,5R)-5-(3-cyclopropyl-...)
Affinity DataIC50: 345nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM395689(US10308645, Example 28 | (2R,5R)-5-(3-cyclopropyl-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent