BDBM394600 2-(6-(methylamino)pyridazin-3-yl)phenol::US10308614, Example 204

SMILES CNc1ccc(nn1)-c1ccccc1O

InChI Key InChIKey=UWHKFKASLJRTNP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 394600   

TargetTranscription activator BRG1 [1448-1575](Human)
Genentech

US Patent
LigandPNGBDBM394600(US10308614, Example 204 | 2-(6-(methylamino)pyrida...)
Affinity DataIC50: 894nMAssay Description:His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvprgsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNAQ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

LigandPNGBDBM394600(US10308614, Example 204 | 2-(6-(methylamino)pyrida...)
Affinity DataIC50: 1.04E+3nMAssay Description:Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvprgsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetProtein polybromo-1 [645-766](Human)
Genentech

US Patent
LigandPNGBDBM394600(US10308614, Example 204 | 2-(6-(methylamino)pyrida...)
Affinity DataIC50: 349nMAssay Description:Histidine-Flag-PB1-BD5 Bromodomain645-766 (S645-D766; Swiss Prot Q86U86; mhhhhhhasdykddddkgslvprgsSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAI FLRLPSRSELP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent