BDBM394507 2-(6-amino-5-(3-methyl-4-(methylsulfonyl)piperazin-1-yl)pyridazin-3-yl)phenol::US10308614, Example 108

SMILES CC1CN(CCN1S(C)(=O)=O)c1cc(nnc1N)-c1ccccc1O

InChI Key InChIKey=RNFAVDGGNIENKQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 394507   

TargetTranscription activator BRG1 [1448-1575](Human)
Genentech

US Patent
LigandPNGBDBM394507(US10308614, Example 108 | 2-(6-amino-5-(3-methyl-4...)
Affinity DataIC50: 31nMAssay Description:His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvprgsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNAQ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
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LigandPNGBDBM394507(US10308614, Example 108 | 2-(6-amino-5-(3-methyl-4...)
Affinity DataIC50: 35.8nMAssay Description:Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvprgsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
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TargetProtein polybromo-1 [645-766](Human)
Genentech

US Patent
LigandPNGBDBM394507(US10308614, Example 108 | 2-(6-amino-5-(3-methyl-4...)
Affinity DataIC50: 15.9nMAssay Description:Histidine-Flag-PB1-BD5 Bromodomain645-766 (S645-D766; Swiss Prot Q86U86; mhhhhhhasdykddddkgslvprgsSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAI FLRLPSRSELP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent