BDBM394490 2-(6-amino-5-(piperidin-1-yl)pyridazin-3-yl)phenol::US10308614, Example 90

SMILES Nc1nnc(cc1N1CCCCC1)-c1ccccc1O

InChI Key InChIKey=RJVQZTLPHCJXNB-UHFFFAOYSA-N

Data  4 IC50  5 Kd  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 394490   

TargetTranscription activator BRG1 [1448-1575](Human)
Genentech

US Patent
LigandPNGBDBM394490(US10308614, Example 90 | 2-(6-amino-5-(piperidin-1...)
Affinity DataIC50: 34nMAssay Description:His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvprgsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNAQ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

LigandPNGBDBM394490(US10308614, Example 90 | 2-(6-amino-5-(piperidin-1...)
Affinity DataIC50: 45.9nMAssay Description:Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvprgsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetProtein polybromo-1 [645-766](Human)
Genentech

US Patent
LigandPNGBDBM394490(US10308614, Example 90 | 2-(6-amino-5-(piperidin-1...)
Affinity DataIC50: 13.9nMAssay Description:Histidine-Flag-PB1-BD5 Bromodomain645-766 (S645-D766; Swiss Prot Q86U86; mhhhhhhasdykddddkgslvprgsSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAI FLRLPSRSELP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetProtein polybromo-1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM394490(US10308614, Example 90 | 2-(6-amino-5-(piperidin-1...)
Affinity DataKd:  10nMAssay Description:Binding affinity to PBRM1 bromodomain 5 (unknown origin) assessed as dissociation constant by BROMOscan LeadHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein polybromo-1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM394490(US10308614, Example 90 | 2-(6-amino-5-(piperidin-1...)
Affinity DataKd:  40nMAssay Description:Binding affinity to PBRM1 bromodomain 2 (unknown origin) assessed as dissociation constant by BROMOscan LeadHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM394490(US10308614, Example 90 | 2-(6-amino-5-(piperidin-1...)
Affinity DataKd:  90nMAssay Description:Binding affinity to SMARCA2 (unknown origin) assessed as dissociation constant by BROMOscan LeadHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTranscription activator BRG1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM394490(US10308614, Example 90 | 2-(6-amino-5-(piperidin-1...)
Affinity DataKd:  11nMAssay Description:Binding affinity to SMARCA4 (unknown origin) assessed as dissociation constant by BROMOscan LeadHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein polybromo-1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM394490(US10308614, Example 90 | 2-(6-amino-5-(piperidin-1...)
Affinity DataKd:  100nMAssay Description:Binding affinity to wild type PBRM1 bromodomain 2 (unknown origin) assessed as dissociation constant by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM394490(US10308614, Example 90 | 2-(6-amino-5-(piperidin-1...)
Affinity DataIC50: 3.10E+3nMAssay Description:Binding affinity to PXR (unknown origin) by Lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM394490(US10308614, Example 90 | 2-(6-amino-5-(piperidin-1...)
Affinity DataEC50: >2.00E+4nMAssay Description:Binding affinity to LXR alpha (unknown origin) by Lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetOxysterols receptor LXR-beta(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM394490(US10308614, Example 90 | 2-(6-amino-5-(piperidin-1...)
Affinity DataEC50: >2.00E+4nMAssay Description:Binding affinity to LXRbeta (unknown origin) by Lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed