BDBM392778 1′-(4,4-Difluoro-cyclohexyl)-6-[(2-dimethylamino-ethyl)-methyl-amino]-1H,1′H-[4,5′]bibenzimidazolyl-7-carboxamide::US10301305, Example 161

SMILES CN(C)CCN(C)c1cc(-c2ccc3n(cnc3c2)C2CCC(F)(F)CC2)c2nc[nH]c2c1C(N)=O

InChI Key InChIKey=CPEBCJGHKOUXMS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 392778   

TargetPutative glyoxylate/hydroxypyruvate reductase B(Staphylococcus aureus)
Mutabilis

US Patent
LigandPNGBDBM392778(1′-(4,4-Difluoro-cyclohexyl)-6-[(2-dimethyla...)
Affinity DataIC50: 13nMAssay Description:The assay buffer AB contained 50 mM Hepes pH8.0, 10 mM MgCl2, 50 mM KCl, 0.012% Triton-X100, 10 mM DTT and 100 nM Myelin-basic protein. The following...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
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TargetD-alanine--D-alanyl carrier protein ligase(Enterococcus faecalis (strain ATCC 700802 / V583))
Mutabilis

US Patent
LigandPNGBDBM392778(1′-(4,4-Difluoro-cyclohexyl)-6-[(2-dimethyla...)
Affinity DataIC50: 8.10nMAssay Description:The assay buffer AB contained 50 mM Hepes pH8.0, 10 mM MgCl2, 50 mM KCl, 0.012% Triton-X100, 10 mM DTT and 100 nM Myelin-basic protein. The following...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
Go to US Patent

TargetD-alanine--D-alanyl carrier protein ligase(Enterococcus faecium E1679)
Mutabilis

US Patent
LigandPNGBDBM392778(1′-(4,4-Difluoro-cyclohexyl)-6-[(2-dimethyla...)
Affinity DataIC50: 69nMAssay Description:The assay buffer AB contained 50 mM Hepes pH8.0, 10 mM MgCl2, 50 mM KCl, 0.012% Triton-X100, 10 mM DTT and 100 nM Myelin-basic protein. The following...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
Go to US Patent

TargetD-alanine--D-alanyl carrier protein ligase(Streptococcus agalactiae serotype V (strain ATCC B...)
Mutabilis

US Patent
LigandPNGBDBM392778(1′-(4,4-Difluoro-cyclohexyl)-6-[(2-dimethyla...)
Affinity DataIC50: 1.20E+3nMAssay Description:The assay buffer AB contained 50 mM Hepes pH8.0, 10 mM MgCl2, 50 mM KCl, 0.012% Triton-X100, 10 mM DTT and 100 nM Myelin-basic protein. The following...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
Go to US Patent