BDBM392048 US10301272, Example 6/46
SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)N2CC3(C2)CS(=O)(=O)C3)c2ccccc12
InChI Key InChIKey=SYEFCMYUCXUVNI-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 392048
Affinity DataIC50: 7.94nMAssay Description:Cells were incubated for additional 16 h before firefly (FF) luciferase activities were measured sequentially in the same cell extract using a Dual-L...More data for this Ligand-Target Pair
Affinity DataIC50: 7.94nMAssay Description:Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...More data for this Ligand-Target Pair
Affinity DataKd: 2.10nMAssay Description:Binding affinity to recombinant human RORgamma LBD (237 to 497 residues) expressed in Escherichia coli BL21 (DE3) GOLD by 1,8-ANS dye-based thermoflu...More data for this Ligand-Target Pair
Affinity DataKd: >8.50E+4nMAssay Description:Binding affinity to recombinant human RORbeta LBD (201 to 452 residues) expressed in Escherichia coli BL21 (DE3) GOLD by 1,8-ANS dye-based thermofluo...More data for this Ligand-Target Pair
Affinity DataEC50: 120nMAssay Description:Inverse agonist activity at RORgammat in human whole blood assessed as reduction in IL17A productionMore data for this Ligand-Target Pair
Affinity DataIC50: 3.60nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair