BDBM389670 2-(1-acryloylpyrrolidin-3-yl)-5-(4-phenoxyphenyl)oxazole-4-carboxamide::US11345695, Example 48::US11840513, Example 48::US9951056, Example 48

SMILES NC(=O)c1nc(oc1-c1ccc(Oc2ccccc2)cc1)C1CCN(C1)C(=O)C=C

InChI Key InChIKey=GGIHRUCVJLVDHB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 389670   

TargetTyrosine-protein kinase BTK(Human)
Guangzhou Innocare Pharma Tech

US Patent
LigandPNGBDBM389670(US9951056, Example 48 | 2-(1-acryloylpyrrolidin-3-...)
Affinity DataIC50: 500nMAssay Description:1× and 2× assay buffer were made at first. BTK kinase was diluted with 1× assay buffer but substrate was diluted with 2× assay buffer. 1 ul of dilute...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Guangzhou Innocare Pharma Tech

US Patent
LigandPNGBDBM389670(US9951056, Example 48 | 2-(1-acryloylpyrrolidin-3-...)
Affinity DataIC50: 500nMAssay Description:1× and 2× assay buffer were made at first. BTK kinase was diluted with 1× assay buffer but substrate was diluted with 2× assay buffer. 1 ul of dilute...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Guangzhou Innocare Pharma Tech

US Patent
LigandPNGBDBM389670(US9951056, Example 48 | 2-(1-acryloylpyrrolidin-3-...)
Affinity DataIC50: 500nMAssay Description:1x and 2x assay buffer were made at first. BTK kinase was diluted with 1× assay buffer but substrate was diluted with 2× assay buffer. 1 ul of dilute...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Guangzhou Innocare Pharma Tech

US Patent
LigandPNGBDBM389670(US9951056, Example 48 | 2-(1-acryloylpyrrolidin-3-...)
Affinity DataIC50: 500nMAssay Description:The activity of the Examples and Analogs described herein, as inhibitors of BTK are demonstrated and confirmed by pharmacological in vitro assays. Ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2024
Entry Details
Go to US Patent