BDBM389631 6-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)nicotinamide::US11345695, Example 3::US11840513, Example 3::US9951056, Example 3
SMILES NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(CC1)C(=O)C=C
InChI Key InChIKey=MZPVEMOYADUARK-UHFFFAOYSA-N
Data 9 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 389631
Affinity DataIC50: 500nMAssay Description:1× and 2× assay buffer were made at first. BTK kinase was diluted with 1× assay buffer but substrate was diluted with 2× assay buffer. 1 ul of dilute...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:1× and 2× assay buffer were made at first. BTK kinase was diluted with 1× assay buffer but substrate was diluted with 2× assay buffer. 1 ul of dilute...More data for this Ligand-Target Pair
Affinity DataIC50: 4.40nMAssay Description:1x and 2x assay buffer were made at first. BTK kinase was diluted with 1× assay buffer but substrate was diluted with 2× assay buffer. 1 ul of dilute...More data for this Ligand-Target Pair
Affinity DataIC50: 4.40nMAssay Description:1x and 2x assay buffer were made at first. BTK kinase was diluted with 1× assay buffer but substrate was diluted with 2× assay buffer. 1 ul of dilute...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:The activity of the Examples and Analogs described herein, as inhibitors of BTK are demonstrated and confirmed by pharmacological in vitro assays. Ac...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Irreversible inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of BTK phosphorylation at Tyr 223 residue in human Ramos cell incubated for 3 hrs by HTRF-based analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of EGFR autophosphorylation at Tyr1068 residue in EGFR-amplified human A-431 cells preincubated with compound for 1 hrs followed by stimul...More data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Inhibition of FLAG-tagged TEC autophosphorylation in HEK293 cells incubated for 2 hrs by MSD electrochemiluminescence immunoassayMore data for this Ligand-Target Pair