BDBM388678 US10538508, Example 40::US9944624, Ex. 40::methyl 2-((2S,5S)-4-(1-(5-amino-4H-1,2,4-triazol-3-yl)piperidin-4-yl)-5-(4-chlorobenzyl)-2-methylpiperazin-1-yl)acetate

SMILES COC(=O)CN1CC(Cc2ccc(Cl)cc2)N(C[C@@H]1C)C1CCN(CC1)c1nnc(N)[nH]1

InChI Key InChIKey=QMFQFIWQIFUCEU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 388678   

TargetAcidic mammalian chitinase(Human)
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM388678(US9944624, Ex. 40 | methyl 2-((2S,5S)-4-(1-(5-amin...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
Go to US Patent

TargetChitotriosidase-1(Human)
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM388678(US9944624, Ex. 40 | methyl 2-((2S,5S)-4-(1-(5-amin...)
Affinity DataIC50: 550nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
Go to US Patent

TargetAcidic mammalian chitinase(Human)
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM388678(US9944624, Ex. 40 | methyl 2-((2S,5S)-4-(1-(5-amin...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2020
Entry Details
Go to US Patent

TargetChitotriosidase-1(Human)
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM388678(US9944624, Ex. 40 | methyl 2-((2S,5S)-4-(1-(5-amin...)
Affinity DataIC50: 550nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2020
Entry Details
Go to US Patent