BDBM386087 US10287305, Example 29::US10508083, Example 29::US11292766, Example 29::isopropyl cis-3- ((dimethylsulfamoyl)amino)-2- (((1-(pyrimidin-2-yl)piperidin-4- yl)oxy)methyl)piperidine-1- carboxylate

SMILES CC(C)OC(=O)N1CCC[C@H](NS(=O)(=O)N(C)C)[C@@H]1COC1CCN(CC1)c1ncccn1

InChI Key InChIKey=YQNKRWPIJMZRDB-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 386087   

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386087(isopropyl cis-3- ((dimethylsulfamoyl)amino)-2- (((...)
Affinity DataEC50:  17nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386087(isopropyl cis-3- ((dimethylsulfamoyl)amino)-2- (((...)
Affinity DataEC50:  17nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386087(isopropyl cis-3- ((dimethylsulfamoyl)amino)-2- (((...)
Affinity DataEC50:  17nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
Go to US Patent