BDBM385544 US10287278, Example 6::US10647706, Example 6

SMILES CS(=N)(=O)c1c(Cl)ccc(NC(=O)Nc2cccc(F)c2Cl)c1O

InChI Key InChIKey=PNVBBUJSSYAUET-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 385544   

TargetC-X-C chemokine receptor type 2(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM385544(US10287278, Example 6 | US10647706, Example 6)
Affinity DataIC50: 20nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors is determined on a functional test of β-arrest...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetC-X-C chemokine receptor type 1(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM385544(US10287278, Example 6 | US10647706, Example 6)
Affinity DataIC50: 200nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors is determined on a functional test of β-arrest...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetC-X-C chemokine receptor type 1(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM385544(US10287278, Example 6 | US10647706, Example 6)
Affinity DataIC50: 20nMAssay Description:To evaluate the direct interaction of the CXCR2 or CXCR1 receptor with β-arrestin 2, a test of β-arrestin 2 recruitment for CXCR2 or CXCR1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
Go to US Patent

TargetC-X-C chemokine receptor type 2(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM385544(US10287278, Example 6 | US10647706, Example 6)
Affinity DataIC50: 200nMAssay Description:To evaluate the direct interaction of the CXCR2 or CXCR1 receptor with β-arrestin 2, a test of β-arrestin 2 recruitment for CXCR2 or CXCR1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
Go to US Patent