BDBM385057 (2S)-N-[(1S)-1-Cyano-2-{4-[3-(cyclopropylmethyl)-2-oxo-2,3-dihydro-1,3-benzoxazol- 5-yl]phenyl}ethyl]-1,4-oxazepane-2-carboxamide::US10287258, Example 17::US10669245, Example 17::US11117874, Example 17::US11655221, Example 17::US11667615, Example 17::US11680049, Example 17::US20230278969, Example 17

SMILES O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2oc(=O)n(CC3CC3)c2c1)C#N)[C@@H]1CNCCCO1

InChI Key InChIKey=WJXGZWWSCFPECN-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 385057   

TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385057((2S)-N-[(1S)-1-Cyano-2-{4-[3-(cyclopropylmethyl)-2...)
Affinity DataIC50: 6.31nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2023
Entry Details
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TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385057((2S)-N-[(1S)-1-Cyano-2-{4-[3-(cyclopropylmethyl)-2...)
Affinity DataIC50: 6.31nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385057((2S)-N-[(1S)-1-Cyano-2-{4-[3-(cyclopropylmethyl)-2...)
Affinity DataIC50: 6.31nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385057((2S)-N-[(1S)-1-Cyano-2-{4-[3-(cyclopropylmethyl)-2...)
Affinity DataIC50: 6.31nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385057((2S)-N-[(1S)-1-Cyano-2-{4-[3-(cyclopropylmethyl)-2...)
Affinity DataIC50: 6.31nMAssay Description:Examples 1-35: The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385057((2S)-N-[(1S)-1-Cyano-2-{4-[3-(cyclopropylmethyl)-2...)
Affinity DataIC50: 6.31nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385057((2S)-N-[(1S)-1-Cyano-2-{4-[3-(cyclopropylmethyl)-2...)
Affinity DataIC50: 6.31nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of amino methyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2023
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM385057((2S)-N-[(1S)-1-Cyano-2-{4-[3-(cyclopropylmethyl)-2...)
Affinity DataIC50: 6.31nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
Go to US Patent