BDBM384630 4-{[trans-4-(4- acetylpiperazin-1- yl)cyclohexyl]amino} quinazoline-6-carbonitrile::US9932350, 6-2

SMILES CC(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N

InChI Key InChIKey=UDRVLWWCRZFRSU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 384630   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384630(US9932350, 6-2 | 4-{[trans-4-(4- acetylpiperazin-1...)
Affinity DataIC50: 11nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384630(US9932350, 6-2 | 4-{[trans-4-(4- acetylpiperazin-1...)
Affinity DataIC50: 420nMAssay Description:Inhibition of IRAK4 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384630(US9932350, 6-2 | 4-{[trans-4-(4- acetylpiperazin-1...)
Affinity DataIC50: 122nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of 5 mM ATP by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed