BDBM384158 (R)-8-(3-(3,5-dichloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8-aza- spiro[4.5]decan-1- amine::US10280171, Example 45::US10851110, Example 45::US11466017, Example 45
SMILES N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cc(Cl)cc(Cl)c1
InChI Key InChIKey=VYQDVBDNUQZKNH-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 384158
TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System
US Patent
The University of Texas System
US Patent
Affinity DataIC50: 355nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System
US Patent
The University of Texas System
US Patent
Affinity DataIC50: 1.42E+3nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System
US Patent
The University of Texas System
US Patent
Affinity DataIC50: 355nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System
US Patent
The University of Texas System
US Patent
Affinity DataIC50: 355nMAssay Description:Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...More data for this Ligand-Target Pair