BDBM382356 US10273259, Example 69::US10711020, Example 69

SMILES OC1(CCS(=O)(=O)CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1

InChI Key InChIKey=ONXFNBOZJKXCNC-UHFFFAOYSA-N

Data  13 IC50  13 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 382356   

TargetOxysterols receptor LXR-alpha(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM382356(US10273259, Example 69 | US10711020, Example 69)
Affinity DataEC50: >7.50E+3nMAssay Description:Agonist activity at LXRalpha (unknown origin) by Gal4-Luc reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM382356(US10273259, Example 69 | US10711020, Example 69)
Affinity DataEC50:  43nMAssay Description:Inverse agonist activity at RORgammat in human whole blood assessed as inhibition of anti-CD3/anti-CD28 monoclonal antibodies-stimulated IL-17A produ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM382356(US10273259, Example 69 | US10711020, Example 69)
Affinity DataEC50:  24nMAssay Description:Inverse agonist activity at human Gal4-fused RORgammat expressed in human Jurkat cells luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM382356(US10273259, Example 69 | US10711020, Example 69)
Affinity DataEC50:  43nMAssay Description:Inverse agonist activity at RORgammat in CD3 and CD28-stimulated human whole blood assessed as suppression of IL17 incubated for 1 hr before CD3 and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM382356(US10273259, Example 69 | US10711020, Example 69)
Affinity DataEC50:  24nMAssay Description:Inverse agonist activity at human Gal4-fused RORgammat expressed in human Jurkat cells assessed as inhibition of constitutive receptor activity measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM382356(US10273259, Example 69 | US10711020, Example 69)
Affinity DataEC50:  43nMAssay Description:Inverse agonist activity at RORgammat in CD3 and CD28-stimulated human whole blood assessed as reduction in IL17A production incubated for 1 hr befor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-alpha(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM382356(US10273259, Example 69 | US10711020, Example 69)
Affinity DataIC50: 1.00E+4nMAssay Description:Activity at RORalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM382356(US10273259, Example 69 | US10711020, Example 69)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM382356(US10273259, Example 69 | US10711020, Example 69)
Affinity DataEC50:  440nMAssay Description:Inverse agonist activity at RORgammat in CD3/CD28/IL-1/IL-23-stimulated C57/B6 mouse whole blood assessed as reduction in IL17A production incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM382356(US10273259, Example 69 | US10711020, Example 69)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM382356(US10273259, Example 69 | US10711020, Example 69)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at PXR (unknown origin) by Gal4-Luc reporter gene assay)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM382356(US10273259, Example 69 | US10711020, Example 69)
Affinity DataIC50: 1.00E+4nMAssay Description:Activity at LXRalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-beta(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM382356(US10273259, Example 69 | US10711020, Example 69)
Affinity DataIC50: 1.00E+4nMAssay Description:Activity at RORbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM382356(US10273259, Example 69 | US10711020, Example 69)
Affinity DataIC50: 36nMAssay Description:The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
Go to US Patent

TargetOxysterols receptor LXR-beta(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM382356(US10273259, Example 69 | US10711020, Example 69)
Affinity DataIC50: 1.00E+4nMAssay Description:Activity at LXRbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM382356(US10273259, Example 69 | US10711020, Example 69)
Affinity DataIC50: 4.00E+4nMAssay Description:Activity at PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM382356(US10273259, Example 69 | US10711020, Example 69)
Affinity DataEC50:  24nMAssay Description:Inverse agonist activity at full length human RORgammat expressed in human Jurkat cells assessed as inhibition of constitutive receptor activity incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM382356(US10273259, Example 69 | US10711020, Example 69)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant CYP3A4 (unknown origin) using BFC substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM382356(US10273259, Example 69 | US10711020, Example 69)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM382356(US10273259, Example 69 | US10711020, Example 69)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of recombinant CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM382356(US10273259, Example 69 | US10711020, Example 69)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM382356(US10273259, Example 69 | US10711020, Example 69)
Affinity DataEC50: >7.50E+3nMAssay Description:Agonist activity at LXRbeta (unknown origin) by Gal4-Luc reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-beta(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM382356(US10273259, Example 69 | US10711020, Example 69)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at RORbeta (unknown origin) by Gal4-Luc reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-alpha(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM382356(US10273259, Example 69 | US10711020, Example 69)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at RORalpha (unknown origin) by Gal4-Luc reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM382356(US10273259, Example 69 | US10711020, Example 69)
Affinity DataEC50:  13nMAssay Description:Inverse agonist activity at RORgammat in mouse cells by mTh17 assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma [262-507](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM382356(US10273259, Example 69 | US10711020, Example 69)
Affinity DataIC50: 36nMAssay Description:The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
Go to US Patent