BDBM381253 4-Chloro-1,3-dimethyl-1H- pyrazolo[3,4-b]pyridine-5- carboxylic acid (3-trifluoromethyl- phenyl)-amide::US10272074, Example 86

SMILES Cc1nn(C)c2ncc(C(=O)Nc3cccc(c3)C(F)(F)F)c(Cl)c12

InChI Key InChIKey=JVAJFUHTZGHXID-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 381253   

TargetGlucocorticoid receptor(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM381253(4-Chloro-1,3-dimethyl-1H- pyrazolo[3,4-b]pyridine-...)
Affinity DataIC50: 50nMAssay Description:The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
Go to US Patent