BDBM379649 US9926281, Compound 172::US9926281, Compound 409

SMILES CC(CC1(NC(=O)NC1=O)C1CC1)C(=O)N1CCN(CC1)c1cc(Cl)cc(Cl)c1

InChI Key InChIKey=KHOCDFJBVDAQHO-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 379649   

TargetADAMTS5(Rat)
Galapagos

US Patent
LigandPNGBDBM379649(US9926281, Compound 172 | US9926281, Compound 409)
Affinity DataIC50: 11nMAssay Description:ADAMTS-4:The basis for the assay is the cleavage of the substrate TBIS-1 (5-FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMTS4For the do...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM379649(US9926281, Compound 172 | US9926281, Compound 409)
Affinity DataIC50: 17nMAssay Description:ADAMTS-5:Protocol 2: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM379649(US9926281, Compound 172 | US9926281, Compound 409)
Affinity DataIC50: 17nMAssay Description:ADAMTS-5:Protocol 2: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM379649(US9926281, Compound 172 | US9926281, Compound 409)
Affinity DataIC50: 311nMAssay Description:TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM379649(US9926281, Compound 172 | US9926281, Compound 409)
Affinity DataIC50: 311nMAssay Description:TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target72 kDa type IV collagenase(Human)
Galapagos

US Patent
LigandPNGBDBM379649(US9926281, Compound 172 | US9926281, Compound 409)
Affinity DataIC50: 2.00E+4nMAssay Description:MMP2: Protocol 2: The basis for the assay is the cleavage of the substrate 390 MMP FRET substrate I (Anaspec, Catalog n#: AS-27076) by human MMP2 (R&...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target72 kDa type IV collagenase(Human)
Galapagos

US Patent
LigandPNGBDBM379649(US9926281, Compound 172 | US9926281, Compound 409)
Affinity DataIC50: 3.02E+3nMAssay Description:MMP2: Protocol 2: The basis for the assay is the cleavage of the substrate 390 MMP FRET substrate I (Anaspec, Catalog n#: AS-27076) by human MMP2 (R&...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCollagenase 3(Human)
Galapagos

US Patent
LigandPNGBDBM379649(US9926281, Compound 172 | US9926281, Compound 409)
Affinity DataIC50: 2.74E+3nMAssay Description:MMP-13:The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat # AS-27076) by human MMP13 (Chemicon, Cat #CC06...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCollagenase 3(Human)
Galapagos

US Patent
LigandPNGBDBM379649(US9926281, Compound 172 | US9926281, Compound 409)
Affinity DataIC50: 2.74E+3nMAssay Description:MMP-13:The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat # AS-27076) by human MMP13 (Chemicon, Cat #CC06...More data for this Ligand-Target Pair
In DepthDetails
US Patent