BDBM379645 US9926281, Compound 167::US9926281, Compound 408

SMILES C[C@H]1CN(CCN1c1ccc(Cl)c(Cl)c1)C(=O)CCC1(NC(=O)NC1=O)C1CC1

InChI Key InChIKey=VAKWUGCSPIRJRO-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 379645   

TargetADAMTS5(Rat)
Galapagos

US Patent
LigandPNGBDBM379645(US9926281, Compound 408 | US9926281, Compound 167)
Affinity DataIC50: 10nMAssay Description:ADAMTS-4:The basis for the assay is the cleavage of the substrate TBIS-1 (5-FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMTS4For the do...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
Go to US Patent

LigandPNGBDBM379645(US9926281, Compound 408 | US9926281, Compound 167)
Affinity DataIC50: 19nMAssay Description:ADAMTS-5:Protocol 2: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
Go to US Patent

LigandPNGBDBM379645(US9926281, Compound 408 | US9926281, Compound 167)
Affinity DataIC50: 19nMAssay Description:ADAMTS-5:Protocol 2: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
Go to US Patent

LigandPNGBDBM379645(US9926281, Compound 408 | US9926281, Compound 167)
Affinity DataIC50: 4.00E+3nMAssay Description:TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
Go to US Patent

LigandPNGBDBM379645(US9926281, Compound 408 | US9926281, Compound 167)
Affinity DataIC50: 4.00E+3nMAssay Description:TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
Go to US Patent

Target72 kDa type IV collagenase(Human)
Galapagos

US Patent
LigandPNGBDBM379645(US9926281, Compound 408 | US9926281, Compound 167)
Affinity DataIC50: 2.00E+4nMAssay Description:MMP2: Protocol 2: The basis for the assay is the cleavage of the substrate 390 MMP FRET substrate I (Anaspec, Catalog n#: AS-27076) by human MMP2 (R&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
Go to US Patent

Target72 kDa type IV collagenase(Human)
Galapagos

US Patent
LigandPNGBDBM379645(US9926281, Compound 408 | US9926281, Compound 167)
Affinity DataIC50: 1.37E+3nMAssay Description:MMP2: Protocol 2: The basis for the assay is the cleavage of the substrate 390 MMP FRET substrate I (Anaspec, Catalog n#: AS-27076) by human MMP2 (R&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
Go to US Patent

TargetCollagenase 3(Human)
Galapagos

US Patent
LigandPNGBDBM379645(US9926281, Compound 408 | US9926281, Compound 167)
Affinity DataIC50: 4.00E+3nMAssay Description:MMP-13:The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat # AS-27076) by human MMP13 (Chemicon, Cat #CC06...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
Go to US Patent

TargetCollagenase 3(Human)
Galapagos

US Patent
LigandPNGBDBM379645(US9926281, Compound 408 | US9926281, Compound 167)
Affinity DataIC50: 4.00E+3nMAssay Description:MMP-13:The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat # AS-27076) by human MMP13 (Chemicon, Cat #CC06...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
Go to US Patent