BDBM379215 US10266549, Example 123b::US10774092, Example 123b

SMILES COc1cc(ccc1Nc1ncc(c(Nc2ccc3NC(=O)CCc3c2)n1)C(F)(F)F)N1CCOCC1

InChI Key InChIKey=JOXXSOJPNYOSGW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 379215   

TargetSerine/threonine-protein kinase ULK1(Human)
Salk Institute

US Patent
LigandPNGBDBM379215(US10266549, Example 123b | US10774092, Example 123...)
Affinity DataIC50: 200nMAssay Description:Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
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TargetSerine/threonine-protein kinase ULK1(Human)
Salk Institute

US Patent
LigandPNGBDBM379215(US10266549, Example 123b | US10774092, Example 123...)
Affinity DataIC50: 200nMAssay Description:ULK1 inhibition assay is a screening assay to identify compounds that inhibit kinase activity of ULK1 using the ULKtide peptide. In some embodiments,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
Go to US Patent