BDBM378802 N-(1-((1-(4-chlorobenzyl)-1H-pyrazol-4-yl)methyl)azetidin-3-yl)-1-cyclopropyl-1H-1,2,3-triazole-4-carboxamide::US10266526, Compound 985

SMILES Clc1ccc(Cn2cc(CN3CC(C3)NC(=O)c3cn(nn3)C3CC3)cn2)cc1

InChI Key InChIKey=MOWCUCXGYVJUHU-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 378802   

TargetN-lysine methyltransferase SMYD2(Human)
Epizyme

US Patent
LigandPNGBDBM378802(US10266526, Compound 985 | N-(1-((1-(4-chlorobenzy...)
Affinity DataIC50: 3.90nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% Bovine Skin Gelatin, and 0.002% Tween20, prepared on...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetN-lysine methyltransferase SMYD2(Human)
Epizyme

US Patent
LigandPNGBDBM378802(US10266526, Compound 985 | N-(1-((1-(4-chlorobenzy...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of FLAG and C-terminally Avi-tagged full length SMYD2 (unknown origin) expressed in Sf9 cells using SAM and histone H3 (1 to 29 residues) ...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetN-lysine methyltransferase SMYD2(Human)
Epizyme

US Patent
LigandPNGBDBM378802(US10266526, Compound 985 | N-(1-((1-(4-chlorobenzy...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human SMYD2 overexpressing human KYSE-150 cells assessed as SMYD2 assessed as reduction in BTF3 monomethylation by Western blot analysi...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)