BDBM375516 N-(1-(4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-6-yl)benzoyl)piperidin-4-yl)acetamide::US9908886, Example 57

SMILES CC(=O)NC1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1

InChI Key InChIKey=FNULKWHYIAWQMD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 375516   

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM375516(US9908886, Example 57 | N-(1-(4-(3-(4-cyanophenyl)...)
Affinity DataIC50: 100nMAssay Description:MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
Go to US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM375516(US9908886, Example 57 | N-(1-(4-(3-(4-cyanophenyl)...)
Affinity DataIC50: 100nMAssay Description:MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
Go to US Patent