BDBM375229 3-chloro-5-(3-fluoropyridin-4-yl)-6-(pyridin-3-yl)pyridin-2-amine::US10253017, Example 23

SMILES Nc1cc(Cl)c(-c2ccnc(F)c2)c(n1)-c1cccnc1

InChI Key InChIKey=JNYHGOGFLOVUNA-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 375229   

TargetRibosyldihydronicotinamide dehydrogenase [quinone](Human)
Palobiofarma

US Patent
LigandPNGBDBM375229(3-chloro-5-(3-fluoropyridin-4-yl)-6-(pyridin-3-yl)...)
Affinity DataIC50: 98nMAssay Description:The experiment of binding to MT3 sites was carried out on hamster brain membranes using [125I]2-iodomelatonin as radioligand in accordance with the p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetAdenosine receptor A2b(Human)
Palobiofarma

US Patent
LigandPNGBDBM375229(3-chloro-5-(3-fluoropyridin-4-yl)-6-(pyridin-3-yl)...)
Affinity DataKi:  23.9nMAssay Description:The binding assay for adenosine A2B receptor subtype was carried out on human recombinant source (HEK-293 cells) and [3H]DPCPX as radioligand, accord...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetAdenosine receptor A2a(Human)
Palobiofarma

US Patent
LigandPNGBDBM375229(3-chloro-5-(3-fluoropyridin-4-yl)-6-(pyridin-3-yl)...)
Affinity DataKi:  4.80E+3nMAssay Description:The binding assay for adenosine A2B receptor subtype was carried out on human recombinant source (HEK-293 cells) and [3H]DPCPX as radioligand, accord...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent