BDBM374724 12-chloro-11-fluoro-13-methyl-6,7,13,14- tetrahydro-1,15-ethenopyrazolo[4,3- f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one::US10246466, Example 52::US10618912, Example 52

SMILES CC1Nc2ccn3ncc(C(=O)NCCOc4ccc(F)c(Cl)c14)c3n2

InChI Key InChIKey=PBBXBBSBAJKYLC-UHFFFAOYSA-N

Data  6 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 374724   

TargetHigh affinity nerve growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374724(US10246466, Example 52 | 12-chloro-11-fluoro-13-me...)
Affinity DataKd:  6.5nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374724(US10246466, Example 52 | 12-chloro-11-fluoro-13-me...)
Affinity DataKd:  270nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374724(US10246466, Example 52 | 12-chloro-11-fluoro-13-me...)
Affinity DataKd:  62nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374724(US10246466, Example 52 | 12-chloro-11-fluoro-13-me...)
Affinity DataKd:  6.5nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374724(US10246466, Example 52 | 12-chloro-11-fluoro-13-me...)
Affinity DataKd:  270nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374724(US10246466, Example 52 | 12-chloro-11-fluoro-13-me...)
Affinity DataKd:  62nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent