BDBM373673 1-(4-(Dimethylamino)-7-chloro-6-isopropylquinazolin-2-yl)-1H-pyrazole-4-carboxylic acid;::US10246442, Example 161::US10975062, Example 161

SMILES CC(C)c1cc2c(nc(nc2cc1Cl)-n1cc(cn1)C(O)=O)N(C)C

InChI Key InChIKey=NDNRLDOEVZSOOW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 373673   

TargetEgl nine homolog 1 [182-426](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM373673(US10246442, Example 161 | 1-(4-(Dimethylamino)-7-c...)
Affinity DataIC50: 39.8nMAssay Description:The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetEgl nine homolog 1 [181-417](Human)
TBA

US Patent
LigandPNGBDBM373673(US10246442, Example 161 | 1-(4-(Dimethylamino)-7-c...)
Affinity DataIC50: 39.8nMAssay Description:The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
Go to US Patent