BDBM373661 1-(6-(Cyclohexyloxy)-4-(diethylamino)-7-fluoroquinazolin-2-yl)-1H-pyrazole-4-carboxylic acid;::US10246442, Example 102::US10975062, Example 102

SMILES CCN(CC)c1nc(nc2cc(F)c(OC3CCCCC3)cc12)-n1cc(cn1)C(O)=O

InChI Key InChIKey=WGZZJYZGXLZUGS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 373661   

TargetEgl nine homolog 1 [182-426](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM373661(US10246442, Example 102 | 1-(6-(Cyclohexyloxy)-4-(...)
Affinity DataIC50: 31.6nMAssay Description:The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetEgl nine homolog 1 [181-417](Human)
TBA

US Patent
LigandPNGBDBM373661(US10246442, Example 102 | 1-(6-(Cyclohexyloxy)-4-(...)
Affinity DataIC50: 31.6nMAssay Description:The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
Go to US Patent