BDBM373605 1-(6-(4-Chlorophenoxy)-4-(diethylamino)quinazolin-2-yl)-1H-pyrazole-4-carboxylic acid;::US10246442, Example 60::US10975062, Example 60

SMILES CCN(CC)c1nc(nc2ccc(Oc3ccc(Cl)cc3)cc12)-n1cc(cn1)C(O)=O

InChI Key InChIKey=ATIPZDSWUMHSTQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 373605   

TargetEgl nine homolog 1 [182-426](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM373605(US10246442, Example 60 | 1-(6-(4-Chlorophenoxy)-4-...)
Affinity DataIC50: 50.1nMAssay Description:The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetEgl nine homolog 1 [181-417](Human)
TBA

US Patent
LigandPNGBDBM373605(US10246442, Example 60 | 1-(6-(4-Chlorophenoxy)-4-...)
Affinity DataIC50: 50.1nMAssay Description:The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
Go to US Patent