BDBM372983 3-[6-(5-fluoropyridin-2-::US10246432, Example 24::US10584111, Ex No. 24::US11584732, Example 24

SMILES COCc1cc(cc(c1)-c1cc(ncn1)-c1ccc(F)cn1)C#N

InChI Key InChIKey=TYAGKBSUIFMOJA-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 372983   

TargetMetabotropic glutamate receptor 5(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM372983(3-[6-(5-fluoropyridin-2- | US10246432, Example 24 ...)
Affinity DataKi:  2.69nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 5(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM372983(3-[6-(5-fluoropyridin-2- | US10246432, Example 24 ...)
Affinity DataKi:  2.69nMAssay Description:Membrane PreparationcDNA encoding the human mGlu5 receptor was transfected into HEK293 cells using the transfection reagent Genejuice (Novagen). Fort...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 5(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM372983(3-[6-(5-fluoropyridin-2- | US10246432, Example 24 ...)
Affinity DataKi:  2.69nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
Go to US Patent