BDBM372982 3-methyl-5-[6-(5-::US10246432, Example 23::US10584111, Ex No. 23::US11584732, Example 23

SMILES Cc1ccc(nc1)-c1cc(ncn1)-c1cc(C)cc(c1)C#N

InChI Key InChIKey=QFPRCSPLBPCSFF-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 372982   

TargetMetabotropic glutamate receptor 5(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM372982(3-methyl-5-[6-(5- | US10246432, Example 23 | US105...)
Affinity DataKi:  2.14nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 5(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM372982(3-methyl-5-[6-(5- | US10246432, Example 23 | US105...)
Affinity DataKi:  2.14nMAssay Description:Membrane PreparationcDNA encoding the human mGlu5 receptor was transfected into HEK293 cells using the transfection reagent Genejuice (Novagen). Fort...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 5(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM372982(3-methyl-5-[6-(5- | US10246432, Example 23 | US105...)
Affinity DataKi:  2.14nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
Go to US Patent