BDBM370258 BDBM467153::US10233188, Example 145

SMILES CS(=O)(=O)N1CCC(CC1)Nc1ncc2cc(CCO)c(=O)n(C3CCCC3)c2n1

InChI Key InChIKey=YWQFJBMWXOICTC-UHFFFAOYSA-N

Data  10 KI  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 370258   

TargetRetinoblastoma-associated protein(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM370258(US10233188, Example 145 | BDBM467153)
Affinity DataIC50: 270nMAssay Description:Inhibition of RB1 phosphorylation in human OVCAR-3 cells assessed as reduction in phosphorylation at Serine 807/811 residue incubated for 1 hr by ELI...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM370258(US10233188, Example 145 | BDBM467153)
Affinity DataEC50:  200nMAssay Description:Inhibition of XO44 binding to CDK2 in human KURAMOCHI cells preincubated with compound by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM370258(US10233188, Example 145 | BDBM467153)
Affinity DataEC50:  4.00E+3nMAssay Description:Inhibition of XO44 binding to CDK1 in human KURAMOCHI cells preincubated with compound by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM370258(US10233188, Example 145 | BDBM467153)
Affinity DataKi:  0.480nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM370258(US10233188, Example 145 | BDBM467153)
Affinity DataKi:  0.920nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM370258(US10233188, Example 145 | BDBM467153)
Affinity DataKi:  1.40nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

LigandPNGBDBM370258(US10233188, Example 145 | BDBM467153)
Affinity DataKi:  1.40nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

LigandPNGBDBM370258(US10233188, Example 145 | BDBM467153)
Affinity DataKi:  1.40nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/17/2022
Entry Details
Go to US Patent

LigandPNGBDBM370258(US10233188, Example 145 | BDBM467153)
Affinity DataKi:  1.41nMAssay Description:The purpose of the CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a flu...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

LigandPNGBDBM370258(US10233188, Example 145 | BDBM467153)
Affinity DataKi:  1.41nMAssay Description:The purpose of the CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a flu...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

LigandPNGBDBM370258(US10233188, Example 145 | BDBM467153)
Affinity DataKi:  1.41nMAssay Description:The mobility shift assay electrophoretically separates the fluorescently labeled peptides (substrate and phosphorylated product) following the kinase...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/17/2022
Entry Details
Go to US Patent

LigandPNGBDBM370258(US10233188, Example 145 | BDBM467153)
Affinity DataKi:  1.60nMAssay Description:Inhibition of CDK2/cyclin E1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM370258(US10233188, Example 145 | BDBM467153)
Affinity DataKi:  132nMAssay Description:Inhibition of CDK9/Cyclin-T1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed