BDBM368203 US10227334, Example (S)-3-(3-Hydroxyphenyl)-4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1- yl)propoxy)phenyl)-2H-chromen-6-ol

SMILES C[C@@H](COc1ccc(cc1)[C@@H]1Oc2ccc(O)cc2C(C)=C1c1cccc(O)c1)N1CC[C@@H](C)C1

InChI Key InChIKey=JPFFAEPFVTWVBI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 368203   

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM368203(US10227334, Example (S)-3-(3-Hydroxyphenyl)-4-meth...)
Affinity DataIC50: 0.130nMAssay Description:MCF-7 cells were adjusted to a concentration of 40,000 cells per mL in RPMI containing 10% FBS and 20 mM HEPES. 16 microliters of the cell suspension...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM368203(US10227334, Example (S)-3-(3-Hydroxyphenyl)-4-meth...)
Affinity DataIC50: 2.80nMAssay Description:Binding affinity to ERalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM368203(US10227334, Example (S)-3-(3-Hydroxyphenyl)-4-meth...)
Affinity DataIC50: 0.100nMAssay Description:Induction of ERalpha degradation in human MCF7 cells in phenol red free RPMI medium containing 5% charcoal dextran-treated FBS incubated for 4 hrs by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM368203(US10227334, Example (S)-3-(3-Hydroxyphenyl)-4-meth...)
Affinity DataIC50: 0.100nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ERalpha protein level after 4 hrs by InCell Western assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed