BDBM367657 7-chloro-N-((1R,2R)-1-(3-chloro-4- cyclopropoxyphenyl)-1-hydroxy-3- (pyrrolidin-1-yl)propan-2-yl)-3,4- dihydro-1H-benzo[4,5]thieno[2,3- c]pyran-1-carboxamide::US10227312, Example 43::US10759769, Example 43

SMILES O[C@@H]([C@@H](CN1CCCC1)NC(=O)C1OCCc2c1sc1cc(Cl)ccc21)c1ccc(OC2CC2)c(Cl)c1

InChI Key InChIKey=HRDJJAKLQZWCLN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 367657   

TargetCeramide glucosyltransferase(Human)
Biomarin Pharmaceutical

US Patent
LigandPNGBDBM367657(US10227312, Example 43 | 7-chloro-N-((1R,2R)-1-(3-...)
Affinity DataIC50: 550nMAssay Description:This assay was modified based on the study by Larsen et al. (J. Lipid Res. 2011, 53, 282). Madin-Darby canine kidney (MDCK) cell lysate was prepared ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
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TargetCeramide glucosyltransferase(Human)
Biomarin Pharmaceutical

US Patent
LigandPNGBDBM367657(US10227312, Example 43 | 7-chloro-N-((1R,2R)-1-(3-...)
Affinity DataIC50: 550nMAssay Description:Protein concentration was determined using BCA assay kit. Sixty micrograms of MDCK cell lysate was incubated with various concentrations of a compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent