BDBM367654 N-((1R,2R)-3-(azetidin-1-yl)-1-(4- cyclopropoxyphenyl)-1-hydroxypropan- 2-yl)-6-(4-fluorophenyl)-3,4- dihydroisoquinoline-1-carboxamide::US10227312, Example 40::US10759769, Example 40

SMILES O[C@@H]([C@@H](CN1CCC1)NC(=O)C1=NCCc2cc(ccc12)-c1ccc(F)cc1)c1ccc(OC2CC2)cc1

InChI Key InChIKey=IXMPVOIXLNPZLP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 367654   

TargetCeramide glucosyltransferase(Human)
Biomarin Pharmaceutical

US Patent
LigandPNGBDBM367654(US10227312, Example 40 | N-((1R,2R)-3-(azetidin-1-...)
Affinity DataIC50: 55nMAssay Description:This assay was modified based on the study by Larsen et al. (J. Lipid Res. 2011, 53, 282). Madin-Darby canine kidney (MDCK) cell lysate was prepared ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
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TargetCeramide glucosyltransferase(Human)
Biomarin Pharmaceutical

US Patent
LigandPNGBDBM367654(US10227312, Example 40 | N-((1R,2R)-3-(azetidin-1-...)
Affinity DataIC50: 55nMAssay Description:Protein concentration was determined using BCA assay kit. Sixty micrograms of MDCK cell lysate was incubated with various concentrations of a compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent