BDBM367638 N-((1R,2R)-1-(3-chloro-4- cyclopropoxyphenyl)-1-hydroxy-3- (pyrrolidin-1-yl)propan-2-yl)-7-(4- fluorophenyl)-1,1-dimethyl-1H- benzo[d][1,2]oxazine-4-carboxamide::US10227312, Example 23::US10759769, Example 23

SMILES CC1(C)ON=C(C(=O)N[C@H](CN2CCCC2)[C@H](O)c2ccc(OC3CC3)c(Cl)c2)c2ccc(cc12)-c1ccc(F)cc1

InChI Key InChIKey=BLERVCDCVVQGQG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 367638   

TargetCeramide glucosyltransferase(Human)
Biomarin Pharmaceutical

US Patent
LigandPNGBDBM367638(US10227312, Example 23 | N-((1R,2R)-1-(3-chloro-4-...)
Affinity DataIC50: 550nMAssay Description:This assay was modified based on the study by Larsen et al. (J. Lipid Res. 2011, 53, 282). Madin-Darby canine kidney (MDCK) cell lysate was prepared ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetCeramide glucosyltransferase(Human)
Biomarin Pharmaceutical

US Patent
LigandPNGBDBM367638(US10227312, Example 23 | N-((1R,2R)-1-(3-chloro-4-...)
Affinity DataIC50: 550nMAssay Description:Protein concentration was determined using BCA assay kit. Sixty micrograms of MDCK cell lysate was incubated with various concentrations of a compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent