BDBM367636 N-((1R,2R)-3-(azetidin-1-yl)-1-(3- chloro-4-cyclopropoxyphenyl)-1- hydroxypropan-2-yl)-7-(4- fluorophenyl)-N-methyl-1H- benzo[d][1,2]oxazine-4-carboxamide::US10227312, Example 21::US10759769, Example 21

SMILES CN([C@H](CN1CCC1)[C@H](O)c1ccc(OC2CC2)c(Cl)c1)C(=O)C1=NOCc2cc(ccc12)-c1ccc(F)cc1

InChI Key InChIKey=WYHKVUAEWORFIM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 367636   

TargetCeramide glucosyltransferase(Human)
Biomarin Pharmaceutical

US Patent
LigandPNGBDBM367636(US10227312, Example 21 | N-((1R,2R)-3-(azetidin-1-...)
Affinity DataIC50: 55nMAssay Description:This assay was modified based on the study by Larsen et al. (J. Lipid Res. 2011, 53, 282). Madin-Darby canine kidney (MDCK) cell lysate was prepared ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
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TargetCeramide glucosyltransferase(Human)
Biomarin Pharmaceutical

US Patent
LigandPNGBDBM367636(US10227312, Example 21 | N-((1R,2R)-3-(azetidin-1-...)
Affinity DataIC50: 55nMAssay Description:Protein concentration was determined using BCA assay kit. Sixty micrograms of MDCK cell lysate was incubated with various concentrations of a compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent