BDBM366918 N-methyl-N-[2-(3- pyridyl)ethyl]-4-[[8- [1-(4,4,4- trifluorobutanoyl)-3,6- dihydro-2H-pyridin-4- yl]-[1,2,4]triazolo[1,5- a]pyridin-2- yl]amino]benzamide::US9873709, Example 2-212

SMILES CN(CCc1cccnc1)C(=O)c1ccc(Nc2nc3c(cccn3n2)C2=CCN(CC2)C(=O)CCC(F)(F)F)cc1

InChI Key InChIKey=PYPRATHDAHADLH-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 366918   

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM366918(N-methyl-N-[2-(3- pyridyl)ethyl]-4-[[8- [1-(4,4,4-...)
Affinity DataKi:  0.230nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM366918(N-methyl-N-[2-(3- pyridyl)ethyl]-4-[[8- [1-(4,4,4-...)
Affinity DataKi:  0.910nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
Go to US Patent