BDBM366670 4-[[8-[4-[4- (difluoromethyl)phenyl]- 4-(hydroxymethyl)- 1-piperidyl]- [1,2,4]triazolo[1,5- a]pyridin-2-yl]amino]- N-methyl-N-(1- methyl-4- piperidyl)benzamide::US9873709, Example 1-267

SMILES CN(C1CCN(C)CC1)C(=O)c1ccc(Nc2nc3c(cccn3n2)N2CCC(CO)(CC2)c2ccc(cc2)C(F)F)cc1

InChI Key InChIKey=MUEQWXNOZJKISS-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 366670   

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM366670(US9873709, Example 1-267 | 4-[[8-[4-[4- (difluorom...)
Affinity DataKi:  0.25nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM366670(US9873709, Example 1-267 | 4-[[8-[4-[4- (difluorom...)
Affinity DataKi:  0.420nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
Go to US Patent